Understanding Collagen Biostimulant Injections

March 1, 2025

People strive for youthful, glowing skin, and it’s easy to understand why. As we age, our skin loses elasticity and volume, leading to fine lines and wrinkles. However, a treatment exists that can help your skin rebuild itself by stimulating natural collagen production: collagen biostimulants.

These advanced injections are changing the way we smooth wrinkles, improve skin texture, and restore a youthful appearance. With results that develop gradually and last longer than many other treatments, collagen biostimulants have become a preferred choice for those seeking non-surgical skin rejuvenation.

In this guide, we’ll explore what collagen biostimulants are, how they work, their benefits, and what to expect from a treatment at Vancouver Laser & Skin Care Centre.

What are collagen biostimulants?

Collagen biostimulants are injectable substances designed to stimulate natural collagen production, helping the skin restore volume, smooth wrinkles, and improve elasticity. These compounds contain biocompatible materials similar to those found in the body, ensuring safe integration into the skin.

Most collagen biostimulants include microbeads or microcrystals made from materials like polylactic acid (PLLA) or calcium hydroxyapatite (CaHA). Once injected, they activate fibroblast cells—the body’s collagen-producing cells—triggering a controlled inflammatory response that leads to gradual collagen regeneration over time.

This process helps reduce wrinkles, improve skin texture, soften acne scars, and boost elastin production, which is essential for maintaining skin firmness and flexibility.

Understanding the differences between dermal fillers vs. biostimulants can help you determine the best treatment for your skin concerns. Unlike traditional dermal fillers, which provide immediate volume, collagen biostimulants gradually enhance the skin by stimulating its natural regenerative processes. This results in longer-lasting, more natural improvements, making biostimulants a popular choice for non-surgical skin rejuvenation.

How do collagen biostimulants work?

Collagen biostimulants mimic the body’s natural healing process. When injected into the dermis, they trigger a controlled inflammatory response, activating fibroblast cells—the body’s collagen-producing cells. This stimulation encourages the formation of new collagen fibers, gradually strengthening and rejuvenating the skin from within.

Since collagen production takes time, the effects of biostimulator injections appear gradually. Small improvements may be visible within a few weeks, but full results develop over several months as collagen regeneration continues.

The longevity of results depends on factors such as the type of biostimulator used, individual body chemistry, and lifestyle habits. Regular maintenance treatments and healthy skincare practices can help extend the benefits of collagen biostimulants.

Common Substances Used in Collagen Biostimulant Injections

Collagen biostimulators are made from a variety of substances, including synthetic and naturally derived materials such as poly-L-lactic acid (PLLA) and calcium hydroxyapatite (CaHA). These compounds encourage the body to produce collagen and elastin, which are essential for maintaining skin firmness and elasticity.

Poly-L-lactic acid (PLLA)  

PLLA is a biodegradable, synthetic substance that gradually stimulates collagen production. When injected, it prompts fibroblast cells to increase collagen output in the treated area. As the body naturally breaks down PLLA, new collagen fibers form, restoring volume and improving skin texture.

Key brand: Sculptra®

  • Commonly used for deeper wrinkles, volume loss in the cheeks, and sagging skin
  • Provides subtle, natural results through gradual improvement rather than an immediate change
  • Results can last up to two years, depending on individual factors

Calcium Hydroxyapatite (CaHA)  

CaHA is a mineral naturally found in bones and teeth. In aesthetic treatments, it is used in dermal fillers composed of small, smooth calcium microspheres suspended in a gel. CaHA offers immediate volume restoration while also stimulating collagen production for longer-lasting effects.

Key brand: Radiesse®

  • Often used for the cheeks, jawline, and nasolabial folds to reduce deep wrinkles and enhance facial contours
  • Provides immediate volume while promoting collagen regeneration over time
  • Offers better lifting and firming effects than some other biostimulants
  • Results can last up to 18 months or longer, depending on the treated area and individual factors

Both Sculptra® and Radiesse® provide unique benefits, depending on individual skin concerns and treatment goals. Sculptra® delivers gradual collagen stimulation for long-term improvement, while Radiesse® provides instant volume with collagen-boosting effects over time.

Collagen biostimulant injection being performed by a practitioner in a clinic

What to Expect During a Collagen Biostimulant Treatment

Collagen biostimulant injections are a quick and straightforward procedure. After your consultation, the practitioner will cleanse the treatment area and may apply a local anesthetic to enhance comfort.

Using fine needles, the biostimulant is then injected into targeted areas to stimulate collagen production. The entire process typically takes 30 to 60 minutes, depending on the number of areas treated. Most patients can return to their daily activities immediately after the session.

Post-Treatment Care

To ensure optimal results, follow these aftercare guidelines:

  • Avoid intense exercise, direct sunlight, and facial massages for at least 24 to 48 hours.
  • Keep the treated area clean and moisturized to support healing.
  • Follow personalized aftercare instructions provided by your practitioner based on your specific treatment plan.

How long do the results last?  

The effects of collagen biostimulant injections can last anywhere from six months to over a year, depending on the product used and the treatment area. As collagen production continues, the improvements become more noticeable, and the skin keeps rejuvenating even after the initial treatment.

Several factors influence how long the results last, including:

  • Skin type and individual healing response
  • Lifestyle choices, such as smoking and sun exposure
  • Regular follow-up treatments to maintain collagen production
  • Proper aftercare, including hydration and sun protection

Consistently following post-treatment recommendations and scheduling maintenance sessions can help extend the longevity of your results.

Benefits of Collagen Biostimulants

Collagen biostimulants offer a range of benefits by stimulating the body’s natural collagen production and supporting skin renewal. These treatments help improve skin texture, restore lost volume, and promote long-term rejuvenation.

Here are the key advantages of collagen biostimulant injections:

Collagen Biostimulants Advantages

Boosts Collagen Production

Collagen biostimulants stimulate the body’s natural collagen production, leading to smoother, firmer, and more youthful-looking skin. As collagen levels increase, the skin appears plumper and more rejuvenated.

Reduces Wrinkles and Fine Lines

By encouraging collagen regeneration, biostimulant injections effectively minimize wrinkles and fine lines caused by aging and sun damage. Over time, the skin becomes smoother, with reduced visibility of lines around the eyes, mouth, and forehead.

Restores Facial Volume

These injections help replenish lost volume in areas such as the cheeks, temples, and under the eyes, creating a subtly lifted, well-balanced appearance that enhances facial contours.

Improves Skin Elasticity

Higher collagen levels result in better skin elasticity, which helps tighten loose skin on the jawline, neck, and lower face. This creates a firmer, more sculpted look.

Long-Lasting Results

Unlike traditional fillers that provide temporary volume, collagen biostimulants work by gradually stimulating natural collagen growth, leading to longer-lasting improvements. Results typically last several months to over a year, depending on individual response and treatment plan.

Minimally Invasive Treatment

Biostimulant injections are a non-surgical, minimally invasive option with little to no downtime. Most people resume normal activities immediately after treatment.

Customizable Treatment

Each treatment is tailored to individual needs, whether the goal is restoring volume, improving skin texture, or reducing sagging. Practitioners can adjust the approach for natural, personalized results.

Potential Side Effects of Collagen Biostimulants

Collagen-stimulating injections, like other injectables, may cause temporary side effects. These are usually mild and resolve quickly.

  • Swelling: Mild swelling is normal after injections and typically subsides within a few hours to a few days. It is most noticeable immediately after treatment but fades as the body heals.
  • Bruising: Some patients may develop a small bruise at the injection site, similar to a pinprick. This usually clears up within a week.
  • Redness: Temporary redness around the injection sites is common due to the needle and should fade within a few hours.

These side effects can be managed with simple care, such as using cold compresses for swelling or avoiding strenuous activity for a short period after treatment.

Rare Side Effects

Although collagen biostimulants are generally safe, there are some rare side effects to be aware of:

  • Nodule Formation: Small lumps may develop under the skin at the injection site as part of the healing process. These usually resolve on their own but, in some cases, may require massage or minor treatments.
  • Allergic Reactions: In rare cases, individuals may experience an allergic reaction to the ingredients used, leading to swelling, itching, or redness beyond the treated area. If these symptoms occur, contact your practitioner immediately.

These uncommon side effects are typically manageable and do not indicate that the treatment is unsafe.

Safety Profile

Collagen biostimulant treatments are considered safe when performed by a qualified practitioner. Substances such as polylactic acid and calcium hydroxyapatite are approved for cosmetic use and have been extensively tested for safety. Most side effects are minor and temporary, with a low risk of serious complications.

To further reduce risks:

  • Ensure that an experienced practitioner performs the treatment.
  • The provider should assess your skin type, medical history, and goals to customize the procedure.
  • Follow all aftercare instructions to minimize potential side effects and ensure the best results.

Choosing a reputable clinic ensures that the procedure is conducted safely, with proper precautions in place to protect your health and achieve natural-looking results.

Choose Vancouver Laser & Skin Care Centre for Your Collagen Biostimulant Treatment

At Vancouver Laser & Skin Care Centre, our experienced team provides advanced aesthetic treatments, including collagen biostimulant injections. We prioritize safety, effectiveness, and personalized care to help you achieve your skin care goals.

Our clinic follows strict safety protocols and uses Health Canada-approved products in a professional, hygienic environment. Every treatment is performed with precision to ensure optimal results and a smooth recovery.

Since every patient’s skin is unique, we develop customized treatment plans to address individual concerns, whether you’re looking to restore volume, improve skin texture, or reduce fine lines. Our approach ensures natural-looking, long-lasting results.

Ready to enhance your skin’s natural beauty? Schedule your safe cosmetic injections in Vancouver today and discover how collagen biostimulant treatments can rejuvenate your skin for a youthful, radiant glow.

Conclusion 

Collagen biostimulants offer an innovative approach to enhancing your skin’s natural beauty by stimulating collagen production. They help reduce wrinkles, restore volume, and improve skin texture while remaining minimally invasive and fully customizable to individual needs.

With proper aftercare, the results can be long-lasting, keeping your skin looking youthful and refreshed. If you’re considering collagen biostimulant injections, Vancouver Laser & Skin Care Centre provides expert care in a safe and professional setting. Our team is committed to delivering personalized treatments tailored to your aesthetic goals.Contact Vancouver Laser & Skin Care Centre today to learn how collagen biostimulants, along with other anti-aging skin treatments, can help you achieve a radiant, youthful complexion.

FAQs

1. How often do you get collagen injections?

Typically, two to four times per year, depending on individual factors and the product used.

2. Is collagen injection better than Botox?

Collagen fillers treat static wrinkles, while Botox targets dynamic wrinkles caused by muscle movement. The best choice depends on your needs.

3. Are biostimulator injections safe?

Yes, when performed by a trained professional. Common side effects include swelling, bruising, and redness, which usually subside quickly.

Understanding Collagen Biostimulant Injections

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