Sculptra® vs. Profhilo® vs. Nucleofill: The Ultimate Injectable Guide!

With advancements in non-surgical skin rejuvenation treatments, injectable options like Nucleofill, Sculptra®, and Profhilo® have gained popularity. Each targets different skin concerns, from hydration and elasticity to volume loss and wrinkle reduction. But how do they compare?

This guide explores the key differences and similarities between these three injectables, helping you determine which option aligns with your aesthetic goals.

At Vancouver Laser & Skin Care Centre, we proudly offer Sculptra®, a collagen-boosting injectable that restores facial volume and improves skin texture. While we do not provide Nucleofill or Profhilo, we will explain their mechanisms, benefits, and results to help you make an informed decision.

What is Sculptra®?

Sculptra® is a biostimulatory filler designed to restore facial volume and improve skin texture by stimulating collagen production. Unlike traditional hyaluronic acid-based fillers, which provide instant volume, Sculptra® works gradually to address the underlying causes of aging, such as fine lines, sagging, and volume loss.

Its key ingredient, poly-L-lactic acid (PLLA), is a biodegradable material that has been used in medicine for over 20 years. By encouraging the body to naturally produce collagen, Sculptra® enhances skin firmness and structure over time, leading to long-lasting, natural-looking results.

How does Sculptra® work?

To understand what to expect from Sculptra® treatment, it’s helpful to know how it works. Sculptra® contains PLLA, which triggers a process called collagenesis—the formation of new collagen fibers. When injected into the skin, PLLA particles act as a framework, supporting the growth of new collagen. Over time, the body absorbs these particles, leaving behind newly formed collagen that enhances skin volume and elasticity.

Unlike traditional fillers that provide immediate results but fade over time, Sculptra® builds volume gradually, with effects that can last up to two years.

Where can Sculptra® be used?

Sculptra® is commonly used to treat volume loss in specific areas of the face, including:

• Hollow cheeks and high cheekbones
• Hollow temples
• Lines around the nostrils (nasolabial folds)
• Midface

Beyond facial treatments, Sculptra® can also be used on the body to improve skin texture and firmness in areas such as:

• Buttocks (for enhancement and lifting)
• Sagging underarm skin
• Wrinkles above the knee
• Crepey skin on the chest

What is Nucleofill?

Nucleofill is an advanced injectable treatment designed to rejuvenate the skin by improving hydration, elasticity, and firmness while helping to prevent wrinkles. Unlike traditional skin boosters and dermal fillers that rely on hyaluronic acid, Nucleofill contains polynucleotide-based bio-stimulating gels that stimulate collagen production, enhance skin structure, and provide deep hydration.

While it does not add as much volume as fillers, Nucleofill improves skin quality, texture, and firmness, delivering a natural, refreshed appearance with long-term benefits.

How does Nucleofill work?

Nucleofill is composed of polynucleotides, which are long chains of nucleic acids that naturally occur in the body. These molecules activate two key receptors in fibroblasts:

• Receptor CD39, which stimulates type 1 collagen production, improving skin firmness.
• Receptor CD40, which promotes fibroblast maturation into myofibroblasts, further enhancing skin structure and elasticity.

In addition to its collagen-boosting effects, Nucleofill has unique hydrophilic properties, meaning it can bind to water molecules at a high capacity. This deeply hydrates the skin, restoring moisture balance while providing a firming and lifting effect.

Where can Nucleofill be used?

Nucleofill is primarily used to rejuvenate the face and neck, though it can also improve skin texture in other areas. Common treatment areas include:

• Forehead
• Cheeks
• Jawline & Chin
• Hands

For facial injections, practitioners target specific points to optimize results and ensure treatment safety. These include:

• Zygomatic Arch – Enhances the mid-face and cheek lift.
• Nasal Base – Improves skin laxity around the nose and mouth.
• Chin – Defines the chin and smooths texture.
• Mandibular Angle – Contours the lower jaw and reduces sagging.

What is Profhilo®?

Profhilo® is an injectable treatment designed to improve skin hydration, elasticity, and overall firmness. It contains a high concentration of hyaluronic acid (HA), making it suitable for individuals with skin that lacks volume and moisture. 

Unlike traditional fillers that primarily add volume, Profhilo® gradually releases HA to stimulate collagen and elastin production, enhancing skin tone and reducing the appearance of fine lines.

How does Profhilo® work?

Profhilo® delivers hyaluronic acid deep into the skin, where it attracts and retains moisture while stimulating collagen and elastin production. 

Unlike standard HA fillers that remain localized, Profhilo® spreads evenly under the skin, providing deep hydration and a subtle lifting effect. This process improves skin texture, enhances firmness, and revitalizes overall skin tone.

Where can Profhilo® be used?

Profhilo® is commonly used to treat the face but can also be applied to other areas of the body to improve hydration and skin quality. Treatment areas include:

• Neck
• Décolleté
• Inner arms
• Hands
• Knees
• Stomach

The Benefits and Outcomes of Sculptra®, Nucleofill, and Profhilo®

Each injectable treatment offers distinct benefits tailored to different skin concerns. Whether your goal is to restore volume, enhance hydration, or improve skin elasticity, understanding the advantages of Nucleofill, Sculptra®, and Profhilo® will help determine the best option for your needs.

Sculptra® Benefits

• Restores volume in areas like the cheeks and temples affected by aging
• Smooths deep wrinkles and fine lines by stimulating collagen production
• Improves skin texture, increasing thickness and radiance
• Provides long-lasting results, with effects lasting up to two years

Nucleofill Benefits

• Improves skin elasticity by increasing firmness and reducing early signs of sagging
• Deeply hydrates the skin, resulting in a smoother, plumper complexion
• Promotes tissue regeneration by stimulating fibroblasts for ongoing skin repair
• Provides a natural look, enhancing skin quality without altering facial features

Profhilo® Benefits

• Delivers intense hydration, deeply moisturizing the skin for a healthy glow
• Improves skin firmness by stimulating collagen and elastin production
• Enhances skin radiance, leaving it refreshed and rejuvenated

Longevity of Results: How Long Do the Benefits Last?

The longevity of results varies for each injectable treatment, influencing how often follow-up sessions are needed. The duration depends on the product used and individual skin response.

• Sculptra®: Offers long-lasting results, up to 2 years or more. It gradually restores volume and improves skin texture through collagen stimulation. Maintenance sessions may help extend the effects.
• Nucleofill: Results typically last 6 to 12 months. It stimulates collagen and elastin, but its effects gradually fade. Regular maintenance treatments help sustain hydration and skin elasticity.
• Profhilo®: Provides benefits for 6 to 9 months. While it deeply hydrates and firms the skin, regular treatments are required to maintain a youthful, refreshed look.

Each treatment’s longevity aligns with different skincare goals, so the best choice depends on how often you prefer touch-ups and the specific improvements you seek.

Number of Sessions Required: How Many Treatments Are Needed?

The number of sessions needed for optimal results varies based on the treatment and desired outcome.

• Sculptra®: Generally performed over three sessions, spaced three to five months apart, allowing gradual collagen stimulation and volume restoration.
• Nucleofill: Typically requires two to four sessions, spaced two to four weeks apart, depending on skin condition and treatment goals.
• Profhilo®: Most patients undergo two sessions, spaced four weeks apart, to achieve optimal skin hydration and firmness.

Each treatment follows a customized approach, and maintenance sessions may be recommended based on individual skin response.

Ideal Candidates for Each Treatment  

Each injectable treatment addresses specific skin concerns, so choosing the right one depends on your goals. A key distinction to consider is hydration vs. collagen boosting injections.

• Sculptra®: As one of the collagen biostimulation injections, it is best suited for individuals experiencing significant volume loss, particularly in areas like the cheeks, temples, and nasolabial folds. If you have deep wrinkles or hollow features, Sculptra® for aging skin can help restore structure and firmness.
• Nucleofill: Ideal for those showing early signs of aging, such as loose skin, fine lines, and dryness. It works well for individuals looking to refresh mild signs of aging while promoting skin regeneration.
• Profhilo®: Best for individuals seeking deep hydration and slight skin lifting. This treatment is especially effective for those in their late 30s to 50s who want a non-invasive option to address aging and dryness on the face, neck, and décolletage.

What are the side effects of Sculptra® vs. Nucleofill vs. Profhilo®?

Sculptra®, Nucleofill, and Profhilo® are generally safe, but like all injectable treatments, they can cause temporary side effects. Most reactions are mild and subside within a few hours to a few days, allowing patients to return to normal activities quickly.

Common Side Effects

• Redness, swelling, or bruising at the injection site, usually resolving within a few hours to a couple of days.
• Mild tenderness or sensitivity in the treated area, which fades naturally.

Rare Side Effects

• Sculptra®: In some cases, small lumps or nodules can form at the injection site. These are typically treatable and fade over time. Allergic reactions are extremely rare but possible.
• Nucleofill: Rarely, mild irritation or prolonged swelling may occur, particularly in sensitive areas.
• Profhilo®: A low risk of minor swelling or uneven skin texture immediately after treatment, which subsides quickly.

These injectables are well-tolerated, with rare side effects being manageable. To minimize risks, it is essential to have treatments performed by a skilled, licensed professional using the right techniques. At Vancouver Laser & Skin Care Centre, our experts ensure the safest, most effective Sculptra® treatments with personalized aftercare guidance.

Choose Sculptra® at Vancouver Laser and Skin Care Centre

At Vancouver Laser and Skin Care Centre, we proudly offer Sculptra®, a highly effective treatment for restoring volume and improving skin texture. While Nucleofill and Profhilo® are not available at our clinic, Sculptra® remains a trusted option for clients seeking long-lasting, natural-looking rejuvenation.

If you’re interested in how Sculptra® can enhance your skin, contact us today to schedule a consultation. Our expert team will guide you through the process and help determine if Sculptra® is the right treatment for your aesthetic goals.

Conclusion 

Nucleofill, Sculptra®, and Profhilo® each offer unique benefits for non-surgical skin rejuvenation. Whether your goal is deep hydration, volume restoration, or a subtle lift, understanding the differences in their composition, treatment areas, and longevity can help you choose the right option for your needs.

At Vancouver Laser and Skin Care Centre, we specialize in Sculptra®, a trusted treatment that restores facial volume, smooths wrinkles, and improves skin texture with long-lasting results. If you’re looking to revitalize your skin, our expert team is here to help.

Book your consultation today to explore the benefits of Sculptra® at Vancouver Laser and Skin Care Centre!