In skincare, hydration is essential, and two key ingredients, Hyaluronic Acid (HA) and Polyglutamic Acid (PGA), play a significant role. Both can hydrate your skin and enhance its glow, but which one is better? Or could combining them be the ultimate solution?
If you’re curious about how these hydration-focused skincare treatments boost moisture or which one fits your skin’s needs, you’re in the right place. This guide will explain the benefits of HA and PGA, provide a comparison, and offer tips on incorporating them into your routine. Let’s explore if HA, PGA, or a combination of both is the key to plump, radiant skin!
What is Hyaluronic Acid and how does it work on the skin?
Hyaluronic Acid (HA) is a natural substance found in the skin and connective tissues. It plays a crucial role in maintaining skin health by holding water, which keeps the skin hydrated and plump.
HA can retain up to 1,000 times its weight in water, making it an exceptionally powerful hydrator. When applied topically, it attracts moisture, reduces fine lines and wrinkles, and supports oil balance, making it suitable for all skin types.
Beyond hydration, HA offers anti-inflammatory benefits, soothing irritated skin, which is especially helpful for sensitive or acne-prone individuals. It also enhances skin elasticity and firmness, contributing to a youthful appearance.
HA is a versatile ingredient available in various skincare products, including serums, moisturizers, and masks. Incorporating Hyaluronic Acid into your routine can help you achieve a healthy, hydrated, and glowing complexion.
Key Benefits of Hyaluronic Acid
Here are the benefits of using Hyaluronic Acid:

- Deep Hydration: Replenishes moisture, keeping skin soft and smooth.
- Anti-Aging Properties: Diminishes fine lines and wrinkles by restoring hydration.
- Plumping Effects: Boosts hydration, making skin appear fuller and improving texture.
- Enhanced Skin Elasticity: Improves firmness and provides a youthful glow.
- Soothing Irritated Skin: Calms redness and sensitivity, ideal for reactive or post-treatment skin.
- Non-Comedogenic: Provides hydration without clogging pores, making it suitable for oily and acne-prone skin.
- Skin Barrier Support: Fortifies the skin barrier to prevent moisture loss and shield against damage.
- Boosts Product Absorption: Enhances the efficacy of other skincare products by increasing moisture levels.
How do different types of Hyaluronic Acid work?
Hyaluronic Acid’s incredible versatility lies in its varying molecular weights. Each type of Hyaluronic Acid targets different layers of the skin, delivering tailored hydration. These variations make HA a standout ingredient for addressing diverse skincare needs.
High Molecular Weight (HMW)
This type remains on the skin’s surface, providing instant hydration and forming a barrier to lock in moisture. It’s especially effective for soothing dryness and irritation.
Low Molecular Weight (LMW)
This type penetrates deeper layers of the skin, delivering hydration where it’s most needed. It enhances elasticity and combats early signs of aging.
Ultra-Low Molecular Weight (ULMW)
This type reaches the deepest skin layers, ensuring long-lasting hydration and delivering stronger anti-aging solutions for every skin type.
Hyaluronic Acid hydrates at multiple levels, adapting to your skin’s unique needs. Its versatility makes it an essential ingredient in any skincare routine.
Vancouver Laser & Skin Care Centre’s HA Treatments and Products
At Vancouver Laser & Skin Care Centre, we offer advanced treatments and high-quality products enriched with Hyaluronic Acid (HA), designed to deeply hydrate, rejuvenate, and enhance your skin’s natural radiance. Whether you’re seeking professional treatments or at-home skincare solutions, our HA options cater to all needs, leaving your skin plump, smooth, and glowing.
Introfill HA Boost Treatment
Introfill treatment employs micro-injections to deliver a personalized blend of hyaluronic acid, vitamins, growth factors, and skin-smoothing solutions just beneath the surface. This innovative treatment revitalizes your complexion, providing lasting hydration and a refreshed appearance.
Dr. Braun Miracle Hyaluronic Acid Gel
Available in our online shop, the Dr. Braun Miracle HA Gel is a professional-grade formula containing pure Hyaluronic Acid. This gel delivers deep hydration, minimizes fine lines, and improves elasticity, leaving your skin instantly supple and youthful with daily use.
Alastin HA Immerse Serum
The Alastin HA Immerse Serum enhances the power of Hyaluronic Acid by hydrating, firming, and smoothing your skin while reinforcing its moisture barrier. Its lightweight, fast-absorbing texture makes it ideal for all skin types, delivering a visibly improved tone and texture.
Dermal Fillers
At Vancouver Laser & Skin Care Centre, we use premium dermal fillers such as JUVÉDERM®, Revanesse®, Stylage®, Radiesse®, and Art Fill. These HA-based fillers restore volume, smooth facial lines, and enhance facial symmetry for a rejuvenated, balanced appearance.
Additionally, we offer Sculptra®, a unique poly-L-lactic acid filler that stimulates collagen production to improve skin firmness and volume over time.
Skinvive™
The Skinvive™ treatment hydrates and brightens your skin, leaving it radiant and youthful. Its advanced formula combines hyaluronic acid, minerals, amino acids, and antioxidants to deeply nourish, hydrate, and protect your skin from environmental stressors.
Dr. Braun Miracle B5 Serum
The Dr. Braun Miracle B5 Serum combines Vitamin B5 with Hyaluronic Acid for intense hydration. This serum repairs the skin barrier, supports overall skin health, and restores a healthy glow, making it perfect for dry or compromised skin.
HydraFacial
The multi-step HydraFacial is a transformative treatment that cleanses, exfoliates, and infuses your skin with Hyaluronic Acid. Suitable for all skin types, it delivers immediate improvements in hydration, tone, and texture for a refreshed, dewy finish.
What is Polyglutamic Acid?
Polyglutamic Acid (PGA) is a peptide derived from fermented soybeans or other plant sources. It originates from glutamic acid, an amino acid crucial for maintaining skin health.
Renowned for its exceptional ability to hydrate, PGA is gaining popularity in skincare products. Its moisture-retention properties make it particularly appealing for individuals looking to keep their skin soft, smooth, and hydrated.
Unique Benefits of Polyglutamic Acid
Polyglutamic Acid offers several unique advantages:

- Superior Water Retention: Holds up to four times more water than hyaluronic acid, ensuring prolonged hydration.
- Enhances Natural Moisturizing Factors (NMFs): Strengthens the skin’s natural hydration systems for a healthier, more balanced complexion.
- Strengthens the Skin Barrier: Forms a protective layer to lock in moisture and defend against environmental stressors.
- Improves Skin Texture: Smooths the skin’s surface, creating a radiant, dewy glow.
- Works Synergistically with HA: Prevents hyaluronic acid breakdown, maximizing its hydrating and anti-aging effects when used together.
Key Differences Between Hyaluronic Acid and Polyglutamic Acid
Hyaluronic Acid (HA) and Polyglutamic Acid (PGA) are both excellent hydrators, but they differ significantly in their properties and uses:
- Water Retention: Polyglutamic Acid absorbs up to 5,000 times its weight in water, making it highly effective for intense hydration. In comparison, Hyaluronic Acid holds up to 1,000 times its weight in water.
- Skin Barrier Support: PGA strengthens the skin’s barrier, shielding it from environmental stressors like pollution and UV rays. Its larger molecules sit on the skin’s surface, providing effective hydration and protection.
- Anti-Aging and Exfoliation: While HA doesn’t match PGA in hydration, it excels in anti-aging benefits. It plumps the skin, reducing fine lines and wrinkles, and gently exfoliates, removing dead skin cells for a brighter complexion.
- Best Uses: Polyglutamic Acid is ideal for very dry skin and surface hydration, while Hyaluronic Acid works for deeper hydration and anti-aging solutions.
Comparison Table: Hyaluronic Acid vs. Polyglutamic Acid | ||
---|---|---|
Feature | Hyaluronic Acid (HA) | Polyglutamic Acid (PGA) |
Molecular Size | Multiple Weights for Varied Skin Penetration | Larger Molecules for Surface Hydration |
Hydration Retention | Retains up to 1,000x its Weight in Water | Retains up to 4x More Water Than HA |
Primary Function | Deep Hydration and Anti-aging | Surface Hydration and Barrier Support |
Additional Benefits | Plumping, Elasticity, and Fine Line Reduction | Enhances NMFs and Prevents HA Breakdown |
Ideal Use | For Dry, Dehydrated, or Aging Skin | For Locking in Moisture and Supporting the Barrier |
Which acid is right for your skin type?
Choosing the best acid depends on your skin’s needs and preferences:
- For Dry Skin: Polyglutamic Acid (PGA) is an excellent choice. It retains more water than Hyaluronic Acid (HA) and provides intense surface hydration. PGA also reduces fine lines and wrinkles, making it ideal for anti-aging.
- For All Skin Types: Hyaluronic Acid penetrates deeper into the skin, drawing in moisture. It helps control oil production, making it suitable for oily, sensitive, and acne-prone skin.
Both acids are safe and effective. To avoid irritation, start with a lower concentration and gradually increase it as your skin adjusts. Always follow with a moisturizer to lock in hydration for the best results.

Can you use Hyaluronic Acid and Polyglutamic Acid together?
Absolutely! These two powerhouse ingredients complement each other to deliver enhanced hydration and visible skin benefits.
- Hyaluronic Acid: Penetrates deep into the skin to draw in moisture, leaving it plump and hydrated.
- Polyglutamic Acid: Forms a protective layer on the surface, locking in hydration and reducing wrinkles for a smoother appearance.
How to Incorporate Them Into Your Routine:
- Start with a Clean Face: Wash and tone your skin to prepare it for hydration.
- Apply Hyaluronic Acid First: Use a serum to deeply hydrate your skin. Wait a minute or two for it to absorb.
- Follow with Polyglutamic Acid: Apply a small amount of PGA serum to create a moisture-locking layer. Gently massage it onto your face and neck.
- Seal with a Moisturizer: Finish with your favourite moisturizer to enhance hydration and protect your skin barrier.
This duo works seamlessly to give your skin a radiant, nourished look. Try it for a boost in hydration and long-lasting glow!
Potential Side Effects and Precautions
Hyaluronic Acid (HA) and Polyglutamic Acid (PGA) are safe for most skin types, including sensitive ones. However, proper usage is essential to avoid potential irritation.
Safety Profiles of HA and PGA
- Hyaluronic Acid (HA): Naturally present in the body, HA is highly safe and effective. It doesn’t clog pores and suits all skin types, including oily and acne-prone skin. Irritation is rare unless combined with harsh ingredients.
- Polyglutamic Acid (PGA): Gentle and safe for most users, PGA remains on the skin’s surface, reducing the risk of deeper irritation. It’s well-tolerated even by people with sensitive skin or eczema.
Patch Testing Guidelines
Patch testing helps ensure new products are safe for your skin:
- Apply a small amount to a discreet area, such as your inner wrist or behind your ear.
- Wait 24-48 hours to monitor for redness, itching, or irritation.
If no adverse reactions occur, the product is likely safe for regular use. Patch testing is especially crucial for products with additional active ingredients.
Frequency of Use and Tips
- How Often to Use: Both HA and PGA can be applied twice daily (morning and night). Beginners should start with once-daily use to observe their skin’s response.
- Avoid Overuse: Overapplying can overwhelm the skin, leading to stickiness or reduced effectiveness. Use a pea-sized amount for each application. Pair low molecular weight HA with a moisturizer to prevent dryness.
- Combining with Actives: Avoid using HA or PGA immediately after strong exfoliants or retinoids to minimize sensitivity. Alternate their use (e.g., HA in the morning and retinoids at night) if using multiple actives.
What to Do in Case of Irritation
If you experience redness, itching, or irritation:
- Stop using the product immediately.
- Apply a soothing moisturizer or barrier cream to calm the skin.
- Consult a dermatologist if symptoms persist or worsen.
Conclusion
Hyaluronic acid and polyglutamic acid are two exceptional ingredients for hydrating your skin. Hyaluronic acid penetrates deep into the skin, delivering moisture that plumps the skin and reduces fine lines.
Polyglutamic acid, on the other hand, retains moisture on the surface while strengthening the skin’s natural barrier, ensuring long-lasting hydration. Whether used individually or together, these ingredients can enhance your skincare routine, leaving your skin fresh, radiant, and healthy.
Not sure which acid suits your skin type? At Vancouver Laser & Skin Care Centre, we provide personalized skincare solutions tailored to your needs. With treatments like the Introfill treatment HA Boost and rejuvenating HydraFacial, our experts can help you achieve your best skin.
Book your consultation today and discover how we can elevate your skincare routine. Start your journey to hydrated, glowing skin!
FAQs
1. Can I use polyglutamic acid instead of hyaluronic acid?
Yes, polyglutamic acid can replace hyaluronic acid. However, combining both enhances hydration and strengthens the skin barrier for optimal results.
2. Is polyglutamic acid better than hyaluronic acid for dry skin?
Polyglutamic acid is ideal for dry skin due to its superior water retention, delivering long-lasting hydration.
3. How do hyaluronic acid and polyglutamic acid differ in skincare?
Hyaluronic acid attracts moisture to hydrate deeply, while polyglutamic acid locks in water and supports the skin barrier.
4. What are the benefits of combining hyaluronic acid and polyglutamic acid?
Using both acids together improves hydration, fortifies the skin barrier, and ensures effective moisture retention.
5. Are there any side effects of using polyglutamic acid on the skin?
Polyglutamic acid is safe and well-tolerated, with a minimal risk of irritation, even for sensitive skin types.